| Ken Brady lives in Staten Island, New York
close to the waterfront, where he enjoys views northward toward Manhattan and
southeast-ward past the Verazzano-Narrows
Bridge to the Atlantic ocean. Ken is active in various social, musical, spiritual, and professional organizations, including the Natural History Group, Men of All Colors Together, Richmond Choral Society, the Unitarian Churches of Staten Island and Brooklyn Heights, NYPC, and nyc.net Developers' Group. |
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Overview Scientifically trained, versatile software developer with background in pharmaceutical and financial industries.
| Programming languages (C++ w/STL, C#, Visual Basic, XML, XSL, HTML, SQL, VBScript, JavaScript, Fortran, Pascal). |
| Server component development (ATL, COM, ADO/OLEDB, Visual C++, Visual Basic). Windows Services (VC++). Windows Scripting Host development, supporting custom scripting objects (ATL/COM, VC++). |
| Multithreaded application development for data analysis and visualization on Windows/NT (VC++/MFC, C#/.NET) and OS/2 (API programming). |
| Applications and components for database access (custom OLEDB providers, ADO, ODBC/C++, SQL) using SQL Server, Oracle, and Access. Database design and development (Oracle + PL/SQL, SQL Server, Access). |
| Algorithm development (hierarchical clustering, Fourier methods, expression parsing/evaluation, regression analyses, custom). |
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| Dates | Position, Responsibilities, and Achievements |
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| current | Consulting and independent projects
Developed AudioExplorer, a music-analysis application (www.audioonyx.com); software consulting for Always Your Choice medical office; teaching classes in C++ and C# through NYPC, including development of a unique application-centric curriculum; assisted with the NY .NET Developer's group public and administrative websites (www.nycdotnetdev.com). |
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| Sep. '01 - Jan. '02 | Software Engineer, Proteometrics, Inc. (New York, NY) Refactored a major CGI server application written in C to utilize OOP concepts in C++, using XML/XSL technology to facilitate UI customization. |
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| Aug. '00 - Aug. '01 | Software Engineer, Thomson Financial Inc. (New York, NY) Developed, optimized, and maintained COM server applications, including a windows scripting host, a parsing engine for converting a custom query language to a standardized XML intermediate query, and a windows service which monitored and corrected rare data corruptions arriving from a legacy data feed. |
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| '93 - June 2, 2000 | Principal Scientist, BASF Bioresearch Corporation (Worcester, MA). Developed and implemented enzymatic assays to support a full-scale drug development project. Created custom software to facilitate rapid visualization, analysis, and verification of experimental data. Provided database tools to project team to enhance secure and timely sharing of biochemical and pharmacological data among internal and external collaborators. |
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| '95 - Feb. 2000 | Assistant Swimming Coach (Diving Coach), Clark University and Worcester Polytechnic Institute, Departments of Athletics. |
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| '89 - '93 | Postdoctoral Fellow, Harvard School of Public Health, Department of Molecular and Cellular Toxicology (Boston, MA). Synthesized a novel photoaffinity label for the TRH receptor; studies kinetics of TRH-induced GTP exchange; developed software to organize and analyze oscillatory cytosolic calcium fluctuations emanating from individual pituicytes. |
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| '84 - '89 | Doctoral candidate, Brandeis University, Department of Biology (Waltham, MA). Applied organic chemical synthesis, biochemical kinetics, and protein crystallography to understand the mechanism of inhibition of serine proteases by peptidyl trifluoromethyl ketones. |
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| '80 - '83 | Staff Scientist, EIC Laboratories Inc. (Needham, MA). R&D technician in lightweight electrochemical power storage. |
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| Worcester Polytechnic Institute Client/Server Technologies Certification, May 2000 |
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Brandeis University Doctor of Philosophy in Biochemistry July 1989 |
| Massachusetts Institute of Technology Bachelor of Science in Life Sciences January 1980 |
| Microsoft Certified Professional (C# / Windows Forms) |
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Title |
Authors |
Journal / Year |
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Structure-Based Design of Nonpeptide Inhibitors of Interleukin-1b Converting Enzyme (ICE, Caspase-1) |
Aurash B. Shahripour, Mark S. Plummer, Elizabeth A. Lunney, Hans P. Albrecht, Sheryl J. Hays, Catherine B. Kostlan, Tomi K. Sawyer, Nigel P.C. Walker, Kenneth D. Brady, Hamish J. Allen, Robert V. Talanian, Winnie W. Wong, and Christine Humblet |
Bioorganic & Medicinal Chemistry 10:31-40 (2002) |
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Caspases as Targets for Anti-Inflammatory and Anti-Apoptotic Drug Discovery |
Robert V. Talanian, Kenneth D. Brady, and Vincent L. Cryns |
Journal of Medicinal Chemistry, 43:3351-3371 (2000) |
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A Catalytic Mechanism for Caspase-1 and for Bimodal Inhibition of Caspase-1 by Activated Aspartic Ketones |
Kenneth D. Brady, David A. Giegel, Christine Grinnell, Elizabeth Lunney, Robert V. Talanian, Winnie Wong, and Nigel Walker |
Bioorganic and Medicinal Chemistry, 7:621-631 (1999) |
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Bimodal Inhibition of Caspase-1 by Aryloxy- and Acyloxymethyl Ketones |
Kenneth D. Brady |
Biochemistry 37:8058-8515 (1998) |
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Rapid optimization of an ICE inhibitor synthesis using multiple reaction conditions in a parallel array. |
Warmus, Joseph S., Ryder, Todd R., Hodges, John C., Kennedy, Robert M., Brady, Kenneth D. |
Bioorg. Med. Chem. Lett. 8:2309-2314 (1998) |
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Substrate Specificities of Caspase (Interleukin-1b Converting Enzyme) Family Proteases |
Talanian, R. V., Quinlan, C., Trautz, S., Hackett, M. C., Mankovich, J. A., Banach, D., Ghayur, T., Brady, K. D., and Wong, W. W. |
Journal of Biological Chemistry 272:9677-9682 (1997) |
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Preparation of an Autolysis-Resistant Interleukin-1b Converting Enzyme Mutant |
Luan C. Dang, Robert V. Talanian, David Banach, Maria C. Hackett, John L. Gilmore, Sheryl J. Hays, John A. Mankovich, and Kenneth D. Brady |
Biochemistry 35:14910-14916 (1996) |
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Stability and Oligomeric Equilibria of Refolded Interleukin-1b Converting Enzyme |
Robert V. Talanian, Luan C. Dang, Catherine R. Ferenz, Maria C. Hackett, John A. Mankovich, Jeffrey P. Welch, Winnie W. Wong, and Kenneth D. Brady |
Journal of Biological Chemistry 271:21853-21858 (1996) |
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Inhibition of ICE family Proteases by Baculovirus Anti-Apoptotic Protein P35 |
Nancy J. Bump, Maria Hackett, Margaret Hugunin, Somasekar Seshagiri, Kenneth Brady, Patrick Chen, Catherine Ferenz, Simon Franklin, Tariq Ghayur, Ping Li, Peter Licari, John Mankovich, Lianfa Shi, Arnold H. Greenberg, Lois K. Miller, and Winnie W. Wong |
Science, 269:1885-1888 (1995). |
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Alterations in the frequency and shape of Ca2+ fluctuations in GH4C1 cells induced by thyrotropin-releasing hormone and Bay K 8644 |
Kenneth D. Brady, Kimberly A. Wagner, Armen H. Tashjian, Jr., and David E. Golan |
Biochemical Journal 306:399-406 (1995) |
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Crystal Structure of the Cysteine Protease Interleukin-1b-Converting Enzyme: A (p20/p10)2 Homodimer |
N.P.C. Walker, R.V. Talanian, K.D. Brady, L.C. Dang, N.J. Bump, C.R. Ferenz, S. Franklin, T. Ghayur, M.C. Hackett, L.D. Hammill, L. Herzog, M. Hugunin, W. Houy, J.A. Mankovich, L. McGuiness, E. Orlewicz, M. Paskind, C.A. Pratt, P. Reis, A. Summani, M. Terranova, J.P. Welch, L. Xiong, A. Möller, D.E. Tracey, R. Kamen, and W.W. Wong |
Cell 78:343-352 (1994) |
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Kinetics and Reversibility of Thyrotropin-Releasing Hormone-stimulated Guanine Nucleotide Exchange in Membranes from GH4C1 Cells |
Kenneth D. Brady, Bomie Han, and Armen H. Tashjian, Jr. |
Molecular Pharmacology 46:644-652 (1994) |
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Relationships Between Amplitudes and Kinetics of Rapid Cytosolic Free Calcium Fluctuations in GH4C1 Rat Pituitary Cells: Roles for Diffusion and Calcium-Induced Calcium Release |
Kenneth Brady, Kimberly A. Wagner, Armen H. Tashjian, Jr., David E. Golan |
Biophysical Journal 66:1697-1705 (1994) |
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Synthesis and Characterization of a High Affinity Photoactivatable Analogue of Thyrotropin-releasing Hormone |
Kenneth Brady, Armen H. Tashjian Jr. |
Biochemical Journal 281:179-184 (1992) |
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Inhibition of Chymotrypsin by Peptidyl Trifluoromethyl Ketones: Determinants of Slow-binding Kinetics |
Kenneth Brady, Robert H. Abeles |
Biochemistry 29:7608-7617 (1990) |
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Structure of Chymotrypsin-Trifluoromethyl Ketone Inhibitor Complexes: Comparison of Slowly and Rapidly Equilibrating Inhibitors |
Kenneth Brady, Anzhi Wei, Dagmar Ringe, Robert H. Abeles |
Biochemistry 29:7600-7607 (1990) |
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pH Dependence of the Inhibition of Chymotrypsin by a Peptidyl Trifluoromethyl Ketone |
Kenneth Brady, Tzyy-Chyau Liang, Robert H. Abeles |
Biochemistry 28:9066 (1989) |
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Studies of film formation in thionyl chloride electrolytes |
Holleck, G. L.; Brady, K. D. |
Proc. - Electrochem. Soc. 84-1(Lithium Batteries) (1984) |
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| Allen, Hamish John; Banerjee, Subhashis; Brady, Kenneth Dale; Hodges, John Cooke; Kostlan, Catherine Rose; Talanian, Robert Vincent. (Warner-Lambert Company, USA; BASF A.-G.). "N-substituted glutamic acid derivatives with interleukin-1b converting enzyme inhibitory activity." U.S., 13 pp. US 5744451 |
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| Albrecht, Hans P.; Allen, Hamish John; Brady, Kenneth Dale; Caprathe, Bradley William; Albrecht, Hans-Peter; Boehm, Hans-Joachim; Brady, Kenneth Dale; Eckard, Peter; Kardorff, Uwe; Meyer, Norbert; Schirmer, Ulrich; Talanian, Robert Vincent; Walker, Nigel P. C. (BASF A.-G., Germany). "Preparation of pyrimidotriazinediones as interleukin converting enzyme inhibitors." Ger. Offen., 9 pp. DE 19534164 |
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| Allen, Hamish John; Brady, Kenneth Dale; Bradley; Caprathe, William; Galatsis, Paul; Gilmore, John Lodge; Hays, Sheryl Jeanne; Talanian, Robert Vincent; Walker, Nigel; Warmus, Joseph Scott (Warner-Lambert Company, USA; BASF A.-G.) "Hydroxamate inhibitors of interleukin-1b converting enzyme." U.S., 14 pp. US 5919790 |
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| Allen, Hamish John; Brady, Kenneth Dale; Caprathe, Bradley William; Galatsis, Paul; Gilmore, John Lodge; Hays, Sheryl Jeanne; Talanian, Robert Vincent; Walker, Nigel; Warmus, Joseph Scott. (Warner-Lambert Company, USA; BASF A.-G.). "Preparation of 5-(azacycloalkyloxy)-4-oxo-3-aminopentanoates and analogs as interleukin-1b converting enzyme inhibitors." U.S. (1999), 14 pp. US 5919790 A |
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References are available upon request.
